Dataset Information
Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand.
Ontology highlight
ABSTRACT: Background
Melioidosis is a common community-acquired infectious disease in northeast Thailand associated with overall mortality of approximately 40% in hospitalized patients, and over 70% in severe cases. Ceftazidime is recommended for parenteral treatment in patients with suspected melioidosis. Meropenem is increasingly used but evidence to support this is lacking.Methods
A decision tree was used to estimate the cost-effectiveness of treating non-severe and severe suspected acute melioidosis cases with either ceftazidime or meropenem.Results
Empirical treatment with meropenem is likely to be cost-effective providing meropenem reduces mortality in severe cases by at least 9% and the proportion with subsequent culture-confirmed melioidosis is over 20%.Conclusions
In this context, treatment of severe cases with meropenem is likely to be cost-effective, while the evidence to support the use of meropenem in non-severe suspected melioidosis is not yet available.
SUBMITTER: Hantrakun V
PROVIDER: S-EPMC4553702 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20150513 6
<h4>Background</h4>Melioidosis is a common community-acquired infectious disease in northeast Thailand associated with overall mortality of approximately 40% in hospitalized patients, and over 70% in severe cases. Ceftazidime is recommended for parenteral treatment in patients with suspected melioidosis. Meropenem is increasingly used but evidence to support this is lacking.<h4>Methods</h4>A decision tree was used to estimate the cost-effectiveness of treating non-severe and severe suspected acu ...[more]