Zodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data.

ABSTRACT: Genetic interactions play a critical role in cancer development. Existing knowledge about cancer genetic interactions is incomplete, especially lacking evidences derived from large-scale cancer genomics data. The Cancer Genome Atlas (TCGA) produces multimodal measurements across genomics and features of thousands of tumors, which provide an unprecedented opportunity to investigate the interplays of genes in cancer. We introduce Zodiac, a computational tool and resource to integrate existing knowledge about cancer genetic interactions with new information contained in TCGA data. It is an evolution of existing knowledge by treating it as a prior graph, integrating it with a likelihood model derived by Bayesian graphical model based on TCGA data, and producing a posterior graph as updated and

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC4554190 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature