Safety and Immunogenicity of Full-Dose Trivalent Inactivated Influenza Vaccine (TIV) Compared With Half-Dose TIV Administered to Children 6 Through 35 Months of Age.

ABSTRACT:

Background

Children 6 through 35 months of age are recommended to receive half the dose of influenza vaccine compared with older children and adults.

Methods

This was a 6-site, randomized 2:1, double-blind study comparing full-dose (0.5 mL) trivalent inactivated influenza vaccine (TIV) with half-dose (0.25 mL) TIV in children 6 through 35 months of age. Children previously immunized with influenza vaccine (primed cohort) received 1 dose, and those with no previous influenza immunizations (naive cohort) received 2 doses of TIV. Local and systemic adverse events were recorded. Sera were collected before immunization and 1 month after last dose of TIV. Hemagglutination inhibition antibody testing was performed.

Results

Of the 243 subjects enrolled (32 primed, 211 naive),

SUBMITTER: Halasa NB 

PROVIDER: S-EPMC4554205 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature