CD226 gene polymorphisms are associated with non-small-cell lung cancer in the Chinese Han population.

ABSTRACT:

Background

The immunoglobulin-like glycoprotein CD226 (DNAX accessory molecule-1) represents receptor-activating cytotoxic T lymphocyte and natural killer cells taking part in tumor surveillance, the pathogenesis of inflammation, and autoimmune disorders. The aim of the present study is to analyze the association between polymorphisms rs763361 and rs727088 in the CD226 gene and their impact on the pathogenesis of non-small-cell lung cancer (NSCLC).

Materials and methods

Polymerase chain reaction (PCR)-restriction fragment length polymorphisms (RFLP) were used to genotype the single nucleotide polymorphisms (SNPs) rs763361 and rs727088 of the CD226 gene in 302 NSCLC patients and 389 ethnicity matched healthy controls.

Results

The frequencies of the T allele and TT geno

SUBMITTER: Qiu ZX 

PROVIDER: S-EPMC4554428 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature