F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

ABSTRACT:

Objective

In the context of late-onset Alzheimer's disease (LOAD) over 20 genes have been identified but, aside APOE, all show small effect sizes, leaving a large part of the genetic component unexplained. Admixed populations, such as Caribbean Hispanics, can provide a valuable contribution because of their unique genetic profile and higher incidence of the disease. We aimed to identify novel loci associated with LOAD.

Methods

About 4514 unrelated Caribbean Hispanics (2451 cases and 2063 controls) were selected for genome-wide association analysis. Significant loci were further tested in the expanded cohort that also included related family members (n = 5300). Two AD-like transgenic mice models (J20 and rTg4510) were used to study gene expression. Independent data sets of no

SUBMITTER: Tosto G 

PROVIDER: S-EPMC4554442 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature