Genetic GIScience: Toward a Place-Based Synthesis of the Genome, Exposome, and Behavome.

ABSTRACT: The exposome, defined as the totality of an individual's exposures over the life course, is a seminal concept in the environmental health sciences. Although inherently geographic, the exposome as yet is unfamiliar to many geographers. This article proposes a place-based synthesis, genetic geographic information science (Genetic GISc) that is founded on the exposome, genome+ and behavome. It provides an improved understanding of human health in relation to biology (the genome+), environmental exposures (the exposome), and their social, societal and behavioral determinants (the behavome). Genetic GISc poses three key needs: First, a mathematical foundation for emergent theory; Second, process-based models that bridge biological and geographic scales; Third, biologically plausible estimates o

SUBMITTER: Jacquez GM 

PROVIDER: S-EPMC4554694 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature