Application of Deamidated Gliadin Antibodies in the Follow-Up of Treated Celiac Disease.

ABSTRACT:

Introduction

The role of serological tests such as IgA anti-transglutaminase autoantibodies has become increasingly important in celiac disease (CD) diagnosis. However, the efficiency of these tests for patient follow-up is controversial. We investigated the correlation of 12 different serological tests, including recent deamidated gliadin and actin IgA tests, with villous atrophy (VA) in a retrospective cohort of treated celiac patients.

Materials and methods

Serum samples were collected from 100 treated CD patients who had intestinal biopsy in the course of their follow-up. Antibodies against transglutaminase, deamidated gliadin peptides, and native gliadin were measured, along with IgA anti-actin. The biopsy slides were all blind-reviewed and scored according to Marsh cla

SUBMITTER: de Chaisemartin L 

PROVIDER: S-EPMC4554732 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature