Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation.

ABSTRACT: This review evaluates the viability of delayed reward discounting (DRD), an index of how much an individual devalues a future reward based on its delay in time, for genetically-informed drug abuse prevention. A review of the literature suggests that impulsive DRD is robustly associated with drug addiction and meets most of the criteria for being an endophenotype, albeit with mixed findings for specific molecular genetic influences. Several modes of experimental manipulation have been demonstrated to reduce DRD acutely. These include behavioral strategies, such as mindfulness, reward bundling, and episodic future thinking; pharmacological interventions, including noradrenergic agonists, adrenergic agonists, and multiple monoamine agonists; and neuromodulatory interventions, such as transcra

SUBMITTER: Gray JC 

PROVIDER: S-EPMC4554956 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature