Strand-specific community RNA-seq reveals prevalent and dynamic antisense transcription in human gut microbiota.

ABSTRACT: Metagenomics and other meta-omics approaches (including metatranscriptomics) provide insights into the composition and function of microbial communities living in different environments or animal hosts. Metatranscriptomics research provides an unprecedented opportunity to examine gene regulation for many microbial species simultaneously, and more importantly, for the majority that are unculturable microbial species, in their natural environments (or hosts). Current analyses of metatranscriptomic datasets focus on the detection of gene expression levels and the study of the relationship between changes of gene expression and changes of environment. As a demonstration of utilizing metatranscriptomics beyond these common analyses, we developed a computational and statistical procedure to anal

SUBMITTER: Bao G 

PROVIDER: S-EPMC4555090 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature