15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality worldwide. Detection of promoter hypermethylation of tumor suppressor genes in exfoliated cells from the lung provides an assessment of field cancerization that in turn predicts lung cancer. The identification of genetic determinants for this validated cancer biomarker should provide novel insights into mechanisms underlying epigenetic reprogramming during lung carcinogenesis.

Methods

A genome-wide association study using generalized estimating equations and logistic regression models was conducted in two geographically independent smoker cohorts to identify loci affecting the propensity for cancer-related gene methylation that was assessed by a 12-gene panel interrogated in sputum. All statistical tests

SUBMITTER: Leng S 

PROVIDER: S-EPMC4555640 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature