Relationship between the single nucleotide polymorphisms of β₂-adrenergic receptor 5'-regulatory region and essential hypertension in Chinese Kazakh ethnic minority group.

ABSTRACT:

Objective

To study the correlation of β2-AR gene 5'-regulatory region SNPs and essential hypertension (EH) in Chinese Kazakh ethnic minority group.

Methods

The Sequenom MassArray(®) SNP detection technology was used to detect β2-AR gene 5'-regulatory region SNPs in 150 Xinjiang Kazakh EH patients and 150 controls. Biochemical analyzer was used to detect lipid and other related biochemical parameters. SHEsis and other software were used to analyze linkage disequilibrium and haplotype.

Results

Six loci rs205304 (-1023G/A), rs17108803 (-893T/G), rs12654778 (-654G/A), rs11168070 (-468C/G), rs11959427 (-367C/T) and rs2895795 (-1429T/A) polymorphisms of β2-AR gene 5'-regulatory region were found in the Xinjiang Kazakh populations. While, there was no significant difference

SUBMITTER: Cai W 

PROVIDER: S-EPMC4555733 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature