Meta-analysis of Randomized Controlled Trials of Genotype-Guided vs Standard Dosing of Warfarin.

ABSTRACT:

Background

Warfarin is a widely prescribed anticoagulant, and its effect depends on various patient factors including genotypes. Randomized controlled trials (RCTs) comparing genotype-guided dosing (GD) of warfarin with standard dosing have shown mixed efficacy and safety outcomes. We performed a meta-analysis of all published RCTs comparing GD vs standard dosing in adult patients with various indications of warfarin use.

Methods

We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and relevant references for English language RCTs (inception through March 2014). We performed the meta-analysis using a random effects model.

Results

Ten RCTs with a total of 2,505 patients were included in the meta-analysis. GD compared with standard dosi

SUBMITTER: Dahal K 

PROVIDER: S-EPMC4556123 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature