Mortality after radical cystectomy: impact of obesity versus adiposity after adjusting for skeletal muscle wasting.

ABSTRACT:

Purpose

We assess the impact of obesity, as measured conventionally by body mass index vs excess adiposity as measured by fat mass index, on mortality after radical cystectomy for bladder cancer, adjusting for the presence of skeletal muscle wasting.

Materials and methods

This retrospective cohort study included 262 patients treated with radical cystectomy for bladder cancer between 2000 and 2008 at the Mayo Clinic. Lumbar skeletal muscle and adipose compartment areas were measured on preoperative imaging. Overall survival was compared according to gender specific consensus fat mass index and skeletal muscle index thresholds as well as conventional body mass index based criteria. Predictors of all cause mortality were assessed by multivariable modeling.

Results

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SUBMITTER: Psutka SP 

PROVIDER: S-EPMC4556235 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature