Acute kidney injury: preclinical innovations, challenges, and opportunities for translation.

ABSTRACT:

Background

Acute kidney injury (AKI) is a clinically important condition that has attracted a great deal of interest from the biomedical research community. However, acute kidney injury AKI research findings have yet to be translated into significant changes in clinical practice.

Objective

This article reviews many of the preclinical innovations in acute kidney injury AKI treatment, and explores challenges and opportunities to translate these finding into clinical practice.

Sources of information

MEDLINE, ISI Web of Science.

Findings

This paper details areas in biomedical research where translation of pre-clinical findings into clinical trials is ongoing, or nearing a point where trial design is warranted. Further, the paper examines ways that best practice in

SUBMITTER: Silver SA 

PROVIDER: S-EPMC4556308 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature