Regional Nodal Irradiation in Early-Stage Breast Cancer.

ABSTRACT:

Background

Most women with breast cancer who undergo breast-conserving surgery receive whole-breast irradiation. We examined whether the addition of regional nodal irradiation to whole-breast irradiation improved outcomes.

Methods

We randomly assigned women with node-positive or high-risk node-negative breast cancer who were treated with breast-conserving surgery and adjuvant systemic therapy to undergo either whole-breast irradiation plus regional nodal irradiation (including internal mammary, supraclavicular, and axillary lymph nodes) (nodal-irradiation group) or whole-breast irradiation alone (control group). The primary outcome was overall survival. Secondary outcomes were disease-free survival, isolated locoregional disease-free survival, and distant disease-free surviv

SUBMITTER: Whelan TJ 

PROVIDER: S-EPMC4556358 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature