Characterization of Two Metal Binding Lipoproteins as Vaccine Candidates for Enterococcal Infections.

ABSTRACT:

Background

Enterococcus faecium and faecalis are Gram-positive opportunistic pathogens that have become leading causes of nosocomial infections over the last decades. Especially multidrug resistant enterococci have become a challenging clinical problem worldwide. Therefore, new treatment options are needed and the identification of alternative targets for vaccine development has emerged as a feasible alternative to fight the infections caused by these pathogens.

Results

We extrapolate the transcriptomic data from a mice peritonitis infection model in E. faecalis to identify putative up-regulated surface proteins under infection conditions in E. faecium. After the bionformatic analyses two metal binding lipoproteins were identified to have a high homology (>72%) between the t

SUBMITTER: Romero-Saavedra F 

PROVIDER: S-EPMC4556446 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature