Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin.

ABSTRACT:

Background and purpose

The Munich Wistar Frömter (MWF) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffness and/or vascular remodelling.

Experimental approach

Experiments were performed in mesenteric arteries from 12-week-old MWF, Wistar Kyoto (WKY) and consomic MWF-6(SHR) and MWF-8(SHR) rats in which chromosomes 6 or 8 associated with albuminuria from MWF were replaced by the respective chromosome from spontaneously hypertensive rats (SHR).

Key results

Incremental distensibility, wall stress and strain were reduced, and arterial stiffness was significantly

SUBMITTER: Gil-Ortega M 

PROVIDER: S-EPMC4556477 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature