An Integrated Framework Advancing Membrane Protein Modeling and Design.

ABSTRACT: Membrane proteins are critical functional molecules in the human body, constituting more than 30% of open reading frames in the human genome. Unfortunately, a myriad of difficulties in overexpression and reconstitution into membrane mimetics severely limit our ability to determine their structures. Computational tools are therefore instrumental to membrane protein structure prediction, consequently increasing our understanding of membrane protein function and their role in disease. Here, we describe a general framework facilitating membrane protein modeling and design that combines the scientific principles for membrane protein modeling with the flexible software architecture of Rosetta3. This new framework, called RosettaMP, provides a general membrane representation that interfaces with

SUBMITTER: Alford RF 

PROVIDER: S-EPMC4556676 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature