Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function.

ABSTRACT: Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks. By contrast, schizophrenia (SZ) participants show hypoactivation within these frontal-striatal networks during this motivated anticipatory brain state. Here, we examined neural activation in SZ and HC participants during the anticipatory phase of stimuli that predicted immediate upcoming reward and punishment, and during the feedback/outcome phase, in relation to trait measures of hedonic pleasure and real-world functiona

SUBMITTER: Subramaniam K 

PROVIDER: S-EPMC4556736 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature