Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling.

ABSTRACT: Septa from sheep hearts at 130 days gestation, term, and 14-day-old lambs were used to model the changes in gene expression patterns during the perinatal period using Agilent 15k ovine microarrays. We used Bioconductor for R to model five major patterns of coexpressed genes. Gene ontology and transcription factor analyses using Webgestalt modeled the biological significances and transcription factors of the gene expression patterns. Modeling indicated a decreased expression of genes associated with anatomical development and differentiation during this period, whereas those associated with increased protein synthesis and growth associated with maturation of the endoplasmic reticulum rose to term but did not further increase from the near term expression. Expression of genes associated with

SUBMITTER: Richards EM 

PROVIDER: S-EPMC4556942 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature