Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.

ABSTRACT: Radial glial cells (RGCs) are abundant stem-like non-neuronal progenitors that are important for adult neurogenesis and brain repair, yet little is known about their regulation by neurotransmitters. Here we provide evidence for neuronal-glial interactions via a novel role for dopamine to stimulate RGC function. Goldfish were chosen as the model organism due to the abundance of RGCs and regenerative abilities of the adult central nervous system. A close anatomical relationship was observed between tyrosine hydroxylase-positive catecholaminergic cell bodies and axons and dopamine-D1 receptor expressing RGCs along the ventricular surface of telencephalon, a site of active neurogenesis. A primary cell culture model was established and immunofluorescence analysis indicates that in vitro RGCs fr

SUBMITTER: Xing L 

PROVIDER: S-EPMC4557113 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature