Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways.

ABSTRACT: In vertebrates, mechano-electrical transduction of sound is accomplished by sensory hair cells. Whereas mammalian hair cells are not replaced when lost, in fish they constantly renew and regenerate after injury. In vivo tracking and cell fate analyses of all dividing cells during lateral line hair cell regeneration revealed that support and hair cell progenitors localize to distinct tissue compartments. Importantly, we find that the balance between self-renewal and differentiation in these compartments is controlled by spatially restricted Notch signaling and its inhibition of Wnt-induced proliferation. The ability to simultaneously study and manipulate individual cell behaviors and multiple pathways in vivo transforms the lateral line into a powerful paradigm to mechanistically dissect se

SUBMITTER: Romero-Carvajal A 

PROVIDER: S-EPMC4557215 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature