A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran.

ABSTRACT:

Background & objectives

Inherited thrombophilia is known to be an important risk factor for developing venous thromboembolism. Whether such abnormalities may impact the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) differently is not well defined. This preliminary study was undertaken to compare thrombophilic polymorphism in patients with DVT and PE.

Methods

A total of 35 DVT, 23 DVT/PE, and 37 PE patients admitted to the Hajar Hospital, Shahrekord, Iran, between October 2009 and February 2011 were included in the study and 306 healthy volunteers matched by age and sex from the same geographical area with no history of venous or arterial diseases were included as control group. Factor V Leiden (FV 1691G/A, rs6025), prothrombin (FII 20210G/A), methylen

SUBMITTER: Karimi A 

PROVIDER: S-EPMC4557250 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature