Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle.

ABSTRACT: During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dynein-generated cortical pulling forces, which determine spindle positioning and drive chromosome segregation through spindle elongation. The central spindle should be flexible enough for efficient chromosome segregation while maintaining its structural integrity for reliable cytokinesis. How the cell balances these potentially conflicting requirements is poorly understood. Here, we demonstrate that the central spindle in C. elegans embryos

SUBMITTER: Lee KY 

PROVIDER: S-EPMC4557309 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature