Ontology highlight
ABSTRACT:
SUBMITTER: Crisan M
PROVIDER: S-EPMC4557333 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature communications 20150818
Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic cell lineage outputs. The molecular basis for this heterogeneity is largely unknown. BMP signalling regulates HSCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental stages, its role in HSCs is controversial. Here we show that HSCs in murine fetal liver and the bone marrow are of two types th ...[more]