A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.

ABSTRACT: Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV) infections, are poorly controlled by current therapies. This is due to a lack of understanding of the underlying immunopathological mechanisms. Human studies have identified a number of key immune responses that are associated with RV-induced exacerbations including neutrophilic inflammation, expression of inflammatory cytokines and deficiencies in innate anti-viral interferon. Animal models of COPD exacerbation are required to determine the contribution of these responses to disease pathogenesis. We aimed to develop a short-term mouse model that reproduced the hallmark features of RV-induced exacerbation of COPD. Evaluation of complex protocols involving multiple dose elastase and lipop

SUBMITTER: Singanayagam A 

PROVIDER: S-EPMC4557402 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature