Andrographis paniculata transcriptome provides molecular insights into tissue-specific accumulation of medicinal diterpenes.

ABSTRACT:

Background

Kalmegh (Andrographis paniculata) has been widely exploited in traditional medicine for the treatment of infectious diseases and health disorders. Ent-labdane-related diterpene (ent-LRD) specialized (i.e., secondary) metabolites of kalmegh such as andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, are known for variety of pharmacological activities. However, due to the lack of genomic and transcriptomic information, underlying molecular basis of ent-LRDs biosynthesis has remained largely unknown. To identify candidate genes of the ent-LRD biosynthetic pathway, we performed comparative transcriptome analysis using leaf and root tissues that differentially accumulate ent-LRDs.

Results

De novo assembly of Illumina HiSeq2000 platform-gene

SUBMITTER: Garg A 

PROVIDER: S-EPMC4557604 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature