Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types.

ABSTRACT:

Background

Each cell type found within the human body performs a diverse and unique set of functions, the disruption of which can lead to disease. However, there currently exists no systematic mapping between cell types and the diseases they can cause.

Methods

In this study, we integrate protein-protein interaction data with high-quality cell-type-specific gene expression data from the FANTOM5 project to build the largest collection of cell-type-specific interactomes created to date. We develop a novel method, called gene set compactness (GSC), that contrasts the relative positions of disease-associated genes across 73 cell-type-specific interactomes to map genes associated with 196 diseases to the cell types they affect. We conduct text-mining of the PubMed database to prod

SUBMITTER: Cornish AJ 

PROVIDER: S-EPMC4557825 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature