Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation.

ABSTRACT: Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are related strains capable of inducing severe gastrointestinal disease. For optimal infection, these pathogens actively modulate cellular functions through the deployment of effector proteins in a type three secretion system (T3SS)-dependent manner. In response to enteric pathogen invasion, the Nod-like receptor pyrin domain containing (NLRP) inflammasome has been increasingly recognized as an important cytoplasmic sensor against microbial infection by activating caspase-1 and releasing IL-1β. EPEC and EHEC are known to elicit inflammasome activation in macrophages and epithelial cells; however, whether the pathogens actively counteract such innate immune responses is unknown. Using a series of compound effector-gene

SUBMITTER: Yen H 

PROVIDER: S-EPMC4557958 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature