Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function.

ABSTRACT:

Background

Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sought to identify miRNAs that are differentially expressed in chronic total occlusion (CTO) patients with well or poorly developed collateral arteries.

Methods and results

Forty-one CTO patients undergoing coronary angiography and invasive assessment of their coronary collateralization were dichotomized based on their collateral flow index (CFI). After miRNA profiling was conducted on ao

SUBMITTER: Hakimzadeh N 

PROVIDER: S-EPMC4558025 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature