Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies.

ABSTRACT: Cholangiocarcinoma (CC) encompasses a group of related but distinct malignancies whose lack of a stereotyped genetic signature makes challenging the identification of genomic landscape and the development of effective targeted therapies. Accumulated evidences strongly suggest that the remarkable genetic heterogeneity of CC may be the result of a complex interplay among different causative factors, some shared by most human cancers while others typical of this malignancy. Currently, considerable efforts are ongoing worldwide for the genetic characterization of CC, also using advanced technologies such as next-generation sequencing (NGS). Undoubtedly this technology could offer an unique opportunity to broaden our understanding on CC molecular pathogenesis. Despite this great potential, howe

SUBMITTER: Brandi G 

PROVIDER: S-EPMC4558112 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature