Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells.

ABSTRACT: Recent epidemiological studies showed that metformin, a widely used anti-diabetic drug might prevent certain cancers. Metformin also has an anti-proliferative effect in preclinical studies of both hematologic malignancies as well as solid cancers and clinical studies testing metformin as an anti-cancer drug are in progress. However, all cancer types do not respond to metformin with the same effectiveness or acquire resistance. To understand the mechanism of acquired resistance and possibly its mechanism of action as an anti-proliferative agent, we developed metformin resistant LNCaP prostate cancer cells. Metformin resistant LNCaP cells had an increased proliferation rate, increased migration and invasion ability as compared to the parental cells, and expressed markers of epithelial-mesenc

SUBMITTER: Bansal N 

PROVIDER: S-EPMC4558154 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature