Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance.

ABSTRACT: Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new therapeutic strategies to cisplatin resistance, we evaluated, in a model of lung cancer (H1299 and H460 cell lines), the nature of the pathways leading to cell death. We observed that H1299 displayed a natural resistance to cisplatin due to an inability to trigger an apoptotic response that correlates with the induction of autophagy. However, pharmacological and genetic approaches showed how autophagy was a mechanism associated to cell death rather than to resistance. Indeed, pro-autophagic stimuli such as mTOR or Akt inhibition mediate cell death in both cell lines to a similar extent. We next evaluated the response to a novel platinum compound, monoplatin, able to promote cell death in an

SUBMITTER: Garcia-Cano J 

PROVIDER: S-EPMC4558170 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature