Rate of nicotine metabolism and smoking cessation outcomes in a community-based sample of treatment-seeking smokers.

ABSTRACT:

Background

In samples from controlled randomized clinical trials, a smoker's rate of nicotine metabolism, measured by the 3-hydroxycotinine to cotinine ratio (NMR), predicts response to transdermal nicotine. Replication of this relationship in community-based samples of treatment-seeking smokers may help guide the implementation of the NMR for personalized treatment for nicotine dependence.

Methods

Data from a community-based sample of treatment seeking smokers (N=499) who received 8weeks of transdermal nicotine and 4 behavioral counseling sessions were used to evaluate associations between the NMR and smoking cessation. Secondary outcomes included withdrawal and craving, depression and anxiety, side effects, and treatment adherence.

Results

The NMR was a significant

SUBMITTER: Kaufmann A 

PROVIDER: S-EPMC4558221 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature