The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

ABSTRACT: The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in

SUBMITTER: Sahasrabudhe R 

PROVIDER: S-EPMC4558310 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature