Exposure-response relationships for select cancer and non-cancer health outcomes in a cohort of U.S. firefighters from San Francisco, Chicago and Philadelphia (1950-2009).

ABSTRACT:

Objectives

To examine exposure-response relationships between surrogates of firefighting exposure and select outcomes among previously studied US career firefighters.

Methods

Eight cancer and four non-cancer outcomes were examined using conditional logistic regression. Incidence density sampling was used to match each case to 200 controls on attained age. Days accrued in firefighting assignments (exposed-days), run totals (fire-runs) and run times (fire-hours) were used as exposure surrogates. HRs comparing 75th and 25th centiles of lagged cumulative exposures were calculated using loglinear, linear, log-quadratic, power and restricted cubic spline general relative risk models. Piecewise constant models were used to examine risk differences by time since exposure, age at exp

SUBMITTER: Daniels RD 

PROVIDER: S-EPMC4558385 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature