Neural Firing in the Prefrontal Cortex During Alcohol Intake in Alcohol-Preferring "P" Versus Wistar Rats.

ABSTRACT:

Background

Neural activity within the prefrontal cortex (PFC) is altered by alcohol and alcohol-associated stimuli and is mediated by genetic susceptibility to alcoholism. However, very little is known about how genetic risk of excessive drinking might mediate neural firing in the PFC during alcohol consumption.

Methods

To determine how genetic risk influences alcohol seeking, intake, and neural activity, a Pavlovian alcohol consumption task was used-the 2-Way Cued Access Protocol (2CAP). Alcohol-preferring "P" rats and relatives of their (heterogeneous) founding Wistar population were used for these studies. After acquisition of 2CAP, extinction of responding for alcohol was evaluated by substituting water for alcohol. Following these experiments, in vivo electrophysiologic

SUBMITTER: Linsenbardt DN 

PROVIDER: S-EPMC4558392 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature