Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging.

ABSTRACT:

Purpose

A steady pulsed imaging and labeling (SPIL) scheme is proposed to obtain high-resolution multislice perfusion images of mice brain using standard preclinical MRI equipment.

Theory and methods

The SPIL scheme repeats a pulsed arterial spin labeling (PASL) module together with a short mixing time to extend the temporal duration of the generated PASL bolus to the total experimental time. Multislice image acquisition takes place during the mixing times. The mixing time is also used for magnetization recovery following image acquisition. The new scheme is able to yield multislice perfusion images rapidly. The perfusion kinetic curve can be measured by a multipulsed imaging and labeling (MPIL) scheme, i.e., acquiring single-slice ASL signals before reaching steady-state in

SUBMITTER: Xu J 

PROVIDER: S-EPMC4558394 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature