A Simulation Study of Relative Efficiency and Bias in the Nested Case-Control Study Design.

ABSTRACT:

Purpose

The nested case-control study design, in which a fixed number of controls are matched to each case, is often used to analyze exposure-response associations within a cohort. It has become common practice to sample four or five controls per case; however, previous research has shown that in certain instances, significant gains in relative efficiency can be realized when more controls are matched to each case. This study expanded upon this and investigated the effect of (i) the number of cases, (ii) the strength of the exposure-response, and (iii) the skewness of the exposure distribution on the bias and relative efficiency of the conditional likelihood estimator from a nested case-control study.

Methods

Cohorts were simulated and analyzed using conditional logistic reg

SUBMITTER: Bertke S 

PROVIDER: S-EPMC4558410 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature