The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging.

ABSTRACT: Nanobubbles, which have the potential for ultrasonic targeted imaging and treatment in tumors, have been a research focus in recent years. With the current methods, however, the prepared uniformly sized nanobubbles either undergo post-formulation manipulation, such as centrifugation, after the mixture of microbubbles and nanobubbles, or require the addition of amphiphilic surfactants. These processes influence the nanobubble stability, possibly create material waste, and complicate the preparation process. In the present work, we directly prepared uniformly sized nanobubbles by modulating the thickness of a phospholipid film without the purification processes or the addition of amphiphilic surfactants. The fabricated nanobubbles from the optimal phospholipid film thickness exhibited optima

SUBMITTER: Cai WB 

PROVIDER: S-EPMC4558543 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature