Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex.

ABSTRACT: Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring. Identification of cells that contribute to tissue reorganization in the CNS upon injury is a crucial step to develop novel treatment strategies in regenerative medicine. It has been shown that pericytes contribute to scar formation in the spinal cord. It is further known that ischemia initially triggers pericyte loss in vivo, whilst brain trauma is capable of inducing pericyte detachment from cerebral vessels. These data point towards a significant role of pericytes in CNS injury. The temporal and spatial dynamics of PDGFRß cells and their responses in traumatic brain injury are poorly understood. Here we show that PDGFRß positive cells i

SUBMITTER: Zehendner CM 

PROVIDER: S-EPMC4558600 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature