Cytonuclear Interactions in the Evolution of Animal Mitochondrial tRNA Metabolism.

ABSTRACT: The evolution of mitochondrial information processing pathways, including replication, transcription and translation, is characterized by the gradual replacement of mitochondrial-encoded proteins with nuclear-encoded counterparts of diverse evolutionary origins. Although the ancestral enzymes involved in mitochondrial transcription and replication have been replaced early in eukaryotic evolution, mitochondrial translation is still carried out by an apparatus largely inherited from the α-proteobacterial ancestor. However, variation in the complement of mitochondrial-encoded molecules involved in translation, including transfer RNAs (tRNAs), provides evidence for the ongoing evolution of mitochondrial protein synthesis. Here, we investigate the evolution of the mitochondrial translational ma

SUBMITTER: Pett W 

PROVIDER: S-EPMC4558845 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature