KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes.

ABSTRACT: The Krüppel-like factor and specificity protein (KLF/SP) genes play key roles in critical biological processes including stem cell maintenance, cell proliferation, embryonic development, tissue differentiation, and metabolism and their dysregulation has been implicated in a number of human diseases and cancers. Although many KLF/SP genes have been characterized in a handful of bilaterian lineages, little is known about the KLF/SP gene family in nonbilaterians and virtually nothing is known outside the metazoans. Here, we analyze and discuss the origins and evolutionary history of the KLF/SP transcription factor family and associated transactivation/repression domains. We have identified and characterized the complete KLF/SP gene complement from the genomes of 48 species spanning the Eukary

SUBMITTER: Presnell JS 

PROVIDER: S-EPMC4558859 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature