The Evolution of Bony Vertebrate Enhancers at Odds with Their Coding Sequence Landscape.

ABSTRACT: Enhancers lie at the heart of transcriptional and developmental gene regulation. Therefore, changes in enhancer sequences usually disrupt the target gene expression and result in disease phenotypes. Despite the well-established role of enhancers in development and disease, evolutionary sequence studies are lacking. The current study attempts to unravel the puzzle of bony vertebrates' conserved noncoding elements (CNE) enhancer evolution. Bayesian phylogenetics of enhancer sequences spotlights promising interordinal relationships among placental mammals, proposing a closer relationship between humans and laurasiatherians while placing rodents at the basal position. Clock-based estimates of enhancer evolution provided a dynamic picture of interspecific rate changes across the bony vertebrate

SUBMITTER: Yousaf A 

PROVIDER: S-EPMC4558863 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature