Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome.

ABSTRACT: Long noncoding RNAs (lncRNAs) are one of the most intensively studied groups of noncoding elements. Debate continues over what proportion of lncRNAs are functional or merely represent transcriptional noise. Although characterization of individual lncRNAs has identified approximately 200 functional loci across the Eukarya, general surveys have found only modest or no evidence of long-term evolutionary conservation. Although this lack of conservation suggests that most lncRNAs are nonfunctional, the possibility remains that some represent recent evolutionary innovations. We examine recent selection pressures acting on lncRNAs in mouse populations. We compare patterns of within-species nucleotide variation at approximately 10,000 lncRNA loci in a cohort of the wild house mouse, Mus musculus c

SUBMITTER: Wiberg RA 

PROVIDER: S-EPMC4558870 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature