The effect of dietary resistant starch type 2 on the microbiota and markers of gut inflammation in rural Malawi children.

ABSTRACT:

Background

Resistant starch (RS) decreases intestinal inflammation in some settings. We tested the hypothesis that gut inflammation will be reduced with dietary supplementation with RS in rural Malawian children. Eighteen stunted 3-5-year-old children were supplemented with 8.5 g/day of RS type 2 for 4 weeks. The fecal samples were analyzed for the microbiota, the microbiome, short chain fatty acids, metabolome, and proteins indicative of inflammation before and after the intervention. Subjects served as their own controls.

Results

The consumption of RS changed the composition of the microbiota; at the phylum level Actinobacteria increased, while Firmicutes decreased. Among the most prevalent genera, Lactobacillus was increased and Roseburia, Blautia, and Lachnospiracea ince

SUBMITTER: Ordiz MI 

PROVIDER: S-EPMC4558878 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature