Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria.

ABSTRACT:

Background

Cyanobacteria are well known for the production of a range of secondary metabolites. Whilst recent genome sequencing projects has led to an increase in the number of publically available cyanobacterial genomes, the secondary metabolite potential of many of these organisms remains elusive. Our study focused on the 11 publically available Subsection V cyanobacterial genomes, together with the draft genomes of Westiella intricata UH strain HT-29-1 and Hapalosiphon welwitschii UH strain IC-52-3, for their genetic potential to produce secondary metabolites. The Subsection V cyanobacterial genomes analysed in this study are reported to produce a diverse range of natural products, including the hapalindole-family of compounds, microcystin, hapalosin, mycosporine-like amino acid

SUBMITTER: Micallef ML 

PROVIDER: S-EPMC4558948 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature