Phenotypic convergence in bacterial adaptive evolution to ethanol stress.

ABSTRACT:

Background

Bacterial cells have a remarkable ability to adapt to environmental changes, a phenomenon known as adaptive evolution. During adaptive evolution, phenotype and genotype dynamically changes; however, the relationship between these changes and associated constraints is yet to be fully elucidated.

Results

In this study, we analyzed phenotypic and genotypic changes in Escherichia coli cells during adaptive evolution to ethanol stress. Phenotypic changes were quantified by transcriptome and metabolome analyses and were similar among independently evolved ethanol tolerant populations, which indicate the existence of evolutionary constraints in the dynamics of adaptive evolution. Furthermore, the contribution of identified mutations in one of the tolerant strains was eva

SUBMITTER: Horinouchi T 

PROVIDER: S-EPMC4559166 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature