WiseScaffolder: an algorithm for the semi-automatic scaffolding of Next Generation Sequencing data.

ABSTRACT:

Background

The sequencing depth provided by high-throughput sequencing technologies has allowed a rise in the number of de novo sequenced genomes that could potentially be closed without further sequencing. However, genome scaffolding and closure require costly human supervision that often results in genomes being published as drafts. A number of automatic scaffolders were recently released, which improved the global quality of genomes published in the last few years. Yet, none of them reach the efficiency of manual scaffolding.

Results

Here, we present an innovative semi-automatic scaffolder that additionally helps with chimerae resolution and generates valuable contig maps and outputs for manual improvement of the automatic scaffolding. This software was tested on the newl

SUBMITTER: Farrant GK 

PROVIDER: S-EPMC4559175 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature