Kidney Dysfunction and Markers of Inflammation in the Multicenter AIDS Cohort Study.

ABSTRACT:

Background

Human immunodeficiency virus (HIV)-infected individuals are at higher risk for chronic kidney disease than HIV-uninfected individuals. We investigated whether the inflammation present in treated HIV infection contributes to kidney dysfunction among HIV-infected men receiving highly active antiretroviral therapy.

Methods

The glomerular filtration rate (GFR) was directly measured (using iohexol) along with 12 markers of inflammation in Multicenter AIDS Cohort Study participants. Exploratory factor analysis was used to identify inflammatory processes related to kidney dysfunction. The estimated levels of these inflammatory processes were used in adjusted logistic regression analyses evaluating cross-sectional associations with kidney function outcomes.

Results

SUBMITTER: Abraham AG 

PROVIDER: S-EPMC4559190 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature